| 8/28/2010 | Livingstone Blue Bears 6 @ Virginia State 30 | † |
| 9/11/2010 | West Virginia State Yellow Jackets 21 @ Virginia State 34 | |
| 9/18/2010 | Virginia State 28 @ Norfolk State Spartans 51 | |
| 9/25/2010 | Virginia State 20 @ Chowan Braves 13 | † |
| 10/2/2010 | Virginia State 16 @ Bowie State Bulldogs 15 | † |
| 10/9/2010 | Fayetteville State Broncos 21 @ Virginia State 14 | † |
| 10/14/2010 | Elizabeth City State Vikings 10 @ Virginia State 15 | † |
| 10/23/2010 | Lincoln PA Lions 0 @ Virginia State 42 | † |
| 10/30/2010 | Virginia State 35 @ Virginia Union Panthers 7 | † |
| 11/6/2010 | Virginia State 34 @ St Paul's Fighting Tigers 14 | † |
| 11/13/2010 | Shaw Bears 14 vs Virginia State 7 (Durham NC) | † |