| 8/28/2010 | Bowie State 14 @ Seton Hill Griffons 20 | |
| 9/4/2010 | Bowie State 7 @ Morgan State Golden Bears 14 | |
| 9/11/2010 | Bowie State 7 @ Fayetteville State Broncos 27 | † |
| 9/18/2010 | Bowie State 55 @ Livingstone Blue Bears 6 | † |
| 9/25/2010 | Virginia Union Panthers 27 @ Bowie State 28 | † |
| 10/2/2010 | Virginia State Trojans 16 @ Bowie State 15 | † |
| 10/9/2010 | Bowie State 16 vs St Paul's Fighting Tigers 10 (Roanoke VA) | † |
| 10/16/2010 | Lincoln PA Lions 18 @ Bowie State 24 | † |
| 10/23/2010 | Elizabeth City State Vikings 12 @ Bowie State 20 | † |
| 11/6/2010 | Bowie State 59 @ Chowan Braves 19 | † |