| 9/4/2010 | Urbana 14 @ West Virginia Wesleyan Bobcats 17 | |
| 9/11/2010 | Seton Hill Griffons 13 @ Urbana 44 | |
| 9/18/2010 | Urbana 36 @ Tusculum Pioneers 39 | |
| 9/25/2010 | Urbana 33 @ Walsh Cavaliers 34 | |
| 10/2/2010 | Southwest Baptist Bearcats 50 @ Urbana 21 | |
| 10/9/2010 | Kentucky Wesleyan Panthers 25 @ Urbana 39 | † |
| 10/16/2010 | Urbana 20 @ St Joseph's Pumas 27 | † |
| 10/23/2010 | Charleston WV Golden Eagles 44 @ Urbana 34 | |
| 10/30/2010 | Urbana 42 @ Missouri S&T Miners 25 | † |
| 11/6/2010 | Central State Marauders 12 @ Urbana 40 | † |
| 11/13/2010 | Urbana 32 @ Notre Dame OH Falcons 0 |