| 9/4/2010 | Edinboro 20 @ West Liberty Hilltoppers 19 | |
| 9/11/2010 | Edinboro 16 @ West Chester Golden Rams 14 | † |
| 9/18/2010 | Edinboro 27 @ Cheyney Wolves 21 | † |
| 9/25/2010 | Gannon Golden Knights 0 @ Edinboro 13 | † |
| 10/2/2010 | Indiana PA Crimson Hawks 18 @ Edinboro 0 | † |
| 10/9/2010 | Edinboro 14 @ Slippery Rock Rockets 28 | † |
| 10/16/2010 | Mercyhurst Lakers 22 @ Edinboro 21 1OT | † |
| 10/23/2010 | Edinboro 31 @ Clarion Golden Eagles 14 | † |
| 10/30/2010 | Edinboro 30 @ Lock Haven Bald Eagles 22 | † |
| 11/6/2010 | California PA Vulcans 24 @ Edinboro 0 | † |
| 11/13/2010 | East Stroudsburg Warriors 25 @ Edinboro 28 | † |