| 9/2/2010 | Fairmont State Falcons 27 @ Clarion 16 | |
| 9/11/2010 | Clarion 13 @ Bloomsburg Huskies 41 | † |
| 9/18/2010 | Shippensburg Red Raiders 28 @ Clarion 24 | † |
| 9/25/2010 | California PA Vulcans 24 @ Clarion 9 | † |
| 10/2/2010 | Slippery Rock Rockets 16 @ Clarion 13 | † |
| 10/9/2010 | Clarion 49 @ Lock Haven Bald Eagles 6 | † |
| 10/16/2010 | Clarion 21 @ Indiana PA Crimson Hawks 14 | † |
| 10/23/2010 | Edinboro Scots 31 @ Clarion 14 | † |
| 10/30/2010 | Clarion 11 @ Gannon Golden Knights 10 | † |
| 11/6/2010 | Clarion 14 @ Mercyhurst Lakers 38 | † |
| 11/13/2010 | Millersville Marauders 10 @ Clarion 49 | † |