| 8/28/2010 | Shepherd Rams 35 @ Shippensburg 27 | |
| 9/11/2010 | Gannon Golden Knights 22 @ Shippensburg 19 | † |
| 9/18/2010 | Shippensburg 28 @ Clarion Golden Eagles 24 | † |
| 9/25/2010 | C W Post Pioneers 31 @ Shippensburg 14 | † |
| 10/2/2010 | Shippensburg 24 @ Kutztown Golden Bears 33 | † |
| 10/7/2010 | Shippensburg 43 @ West Chester Golden Rams 44 2OT | † |
| 10/16/2010 | Bloomsburg Huskies 23 @ Shippensburg 3 | † |
| 10/23/2010 | Cheyney Wolves 0 @ Shippensburg 50 | † |
| 10/30/2010 | Millersville Marauders 14 @ Shippensburg 19 | † |
| 11/6/2010 | Shippensburg 20 @ East Stroudsburg Warriors 17 | † |
| 11/13/2010 | Shippensburg 37 @ Mercyhurst Lakers 56 | † |