| 8/28/2010 | Olivet Nazarene Tigers 9 @ West Virginia Tech 31 | |
| 9/2/2010 | West Virginia Tech 10 @ Glenville State Pioneers 44 | |
| 9/11/2010 | West Virginia Tech 21 @ Johnson C Smith Golden Bulls 45 | |
| 9/18/2010 | Bethel TN Wildcats 37 @ West Virginia Tech 31 | † |
| 9/25/2010 | West Virginia Tech 7 @ Cumberland TN Bulldogs 30 | † |
| 10/2/2010 | West Virginia Tech 21 @ Virginia-Wise Highland Cavaliers 56 | † |
| 10/16/2010 | Kentucky Christian Knights 37 @ West Virginia Tech 62 | † |
| 10/23/2010 | Georgetown KY Tigers 52 @ West Virginia Tech 16 | † |
| 10/30/2010 | West Virginia Tech 7 @ Lindsey Wilson Blue Raiders 9 | † |
| 11/6/2010 | West Virginia Tech 36 @ Pikeville Bears 40 | † |
| 11/13/2010 | Campbellsville Tigers 56 @ West Virginia Tech 35 | † |