| 8/28/2010 | Mercyhurst Lakers 23 @ Notre Dame OH 0 | |
| 9/4/2010 | Notre Dame OH 14 @ Lindsey Wilson Blue Raiders 10 | |
| 9/11/2010 | Notre Dame OH 0 @ Fairmont State Falcons 38 | |
| 9/18/2010 | Walsh Cavaliers 34 @ Notre Dame OH 14 | |
| 9/25/2010 | Notre Dame OH 13 @ Taylor Trojans 40 | |
| 10/2/2010 | Notre Dame OH 16 @ Central State Marauders 13 | |
| 10/9/2010 | Notre Dame OH 7 @ St Joseph's Pumas 37 | |
| 10/23/2010 | Marian IN Knights 35 @ Notre Dame OH 22 | |
| 10/30/2010 | North Greenville Crusaders 21 @ Notre Dame OH 14 | † |
| 11/6/2010 | Notre Dame OH 14 @ Kentucky Wesleyan Panthers 28 | |
| 11/13/2010 | Urbana Blue Knights 32 @ Notre Dame OH 0 |