| 9/4/2010 | Southern Connecticut 6 @ Indiana PA Crimson Hawks 16 | |
| 9/11/2010 | West Liberty Hilltoppers 49 @ Southern Connecticut 35 | |
| 9/18/2010 | Southern Connecticut 55 @ Pace Setters 12 | † |
| 9/23/2010 | American Int'l Yellow Jackets 7 @ Southern Connecticut 28 | † |
| 10/1/2010 | Assumption Greyhounds 27 @ Southern Connecticut 23 | † |
| 10/9/2010 | Southern Connecticut 22 @ New Haven Chargers 23 | † |
| 10/16/2010 | Bentley Falcons 36 @ Southern Connecticut 26 | † |
| 10/23/2010 | Southern Connecticut 45 @ Stonehill Skyhawks 21 | † |
| 11/6/2010 | Southern Connecticut 49 @ Merrimack Warriors 32 | † |
| 11/13/2010 | Saint Anselm Hawks 21 @ Southern Connecticut 52 | † |