| 8/28/2010 | North Greenville Crusaders 30 @ Mars Hill 36 | |
| 9/4/2010 | Mars Hill 20 @ Charleston WV Golden Eagles 42 | |
| 9/11/2010 | Mars Hill 41 @ St Augustine's Falcons 12 | |
| 9/18/2010 | Mars Hill 14 @ Charleston Southern Buccaneers 28 | |
| 10/2/2010 | Tusculum Pioneers 39 @ Mars Hill 45 | † |
| 10/9/2010 | Mars Hill 24 @ Lenoir-Rhyne Bears 20 | † |
| 10/16/2010 | Newberry Wolves 36 @ Mars Hill 48 | † |
| 10/21/2010 | Mars Hill 27 @ Carson-Newman Eagles 34 | † |
| 10/30/2010 | Catawba Indians 38 @ Mars Hill 28 | † |
| 11/6/2010 | Mars Hill 29 @ Wingate Bulldogs 48 | † |
| 11/13/2010 | Brevard Tornados 35 @ Mars Hill 28 | † |