| 8/28/2010 | St Paul's 28 @ West Virginia Wesleyan Bobcats 35 | |
| 9/11/2010 | UNC Pembroke Braves 42 @ St Paul's 14 | |
| 9/18/2010 | St Paul's 7 @ St Augustine's Falcons 31 | † |
| 9/25/2010 | Livingstone Blue Bears 6 @ St Paul's 27 | † |
| 10/2/2010 | St Paul's 12 @ Elizabeth City State Vikings 30 | † |
| 10/9/2010 | Bowie State Bulldogs 16 vs St Paul's 10 (Roanoke VA) | † |
| 10/16/2010 | Chowan Braves 31 @ St Paul's 20 | † |
| 10/23/2010 | St Paul's 28 @ Virginia Union Panthers 39 | † |
| 10/30/2010 | St Paul's 16 @ Lincoln PA Lions 13 1OT | † |
| 11/6/2010 | Virginia State Trojans 34 @ St Paul's 14 | † |