| 9/4/2010 | Fayetteville State Broncos 0 @ UNC Pembroke 39 | |
| 9/11/2010 | UNC Pembroke 42 @ St Paul's Fighting Tigers 14 | |
| 9/18/2010 | UNC Pembroke 23 @ Wingate Bulldogs 28 | |
| 9/25/2010 | Carson-Newman Eagles 7 @ UNC Pembroke 30 | |
| 10/2/2010 | UNC Pembroke 28 @ Glenville State Pioneers 14 | |
| 10/9/2010 | UNC Pembroke 13 @ Webber International Warriors 26 | |
| 10/16/2010 | Fairmont State Falcons 0 @ UNC Pembroke 24 | |
| 10/23/2010 | UNC Pembroke 7 @ Winston-Salem State Rams 21 | |
| 10/30/2010 | Concord Mountain Lions 30 @ UNC Pembroke 26 | |
| 11/6/2010 | North Greenville Crusaders 27 @ UNC Pembroke 10 | † |