| 8/28/2010 | Trinity Bible @ Valley City State | |
| 9/2/2010 | Shorter @ Georgia State | |
| 9/4/2010 | Pikeville @ South Alabama | |
| 9/4/2010 | Waldorf @ Trinity Bible | |
| 9/4/2010 | Concordia AL @ West Georgia | |
| 9/11/2010 | Miles @ Concordia AL | |
| 9/11/2010 | Lambuth @ Georgia State | |
| 9/11/2010 | Mayville State @ Trinity Bible | |
| 9/16/2010 | Concordia AL @ Carson-Newman | |
| 9/18/2010 | Jacksonville State @ Georgia State | |
| 9/18/2010 | Nicholls State @ South Alabama | |
| 9/18/2010 | Trinity Bible @ Southwestern Assemblies of God | |
| 9/25/2010 | Georgia State @ Campbell | |
| 9/25/2010 | Edward Waters vs South Alabama | |
| 10/2/2010 | Morehead State @ Georgia State | |
| 10/2/2010 | Trinity Bible @ Haskell | |
| 10/2/2010 | Kentucky Wesleyan @ South Alabama | |
| 10/2/2010 | Concordia AL @ Texas College | |
| 10/9/2010 | Savannah State @ Georgia State | |
| 10/9/2010 | Trinity Bible @ Macalester | |
| 10/9/2010 | Missouri S&T @ South Alabama | |
| 10/9/2010 | Concordia AL @ Stillman | |
| 10/16/2010 | North Carolina Central @ Georgia State | |
| 10/16/2010 | South Alabama @ Lamar | |
| 10/23/2010 | Georgia State @ Old Dominion | |
| 10/23/2010 | South Alabama @ UC Davis | |
| 10/30/2010 | Concordia AL @ Benedict | |
| 10/30/2010 | Georgia State @ South Alabama | † |
| 11/4/2010 | Trinity Bible @ Minnesota-Morris | |
| 11/6/2010 | Lamar @ Georgia State | |
| 11/6/2010 | Concordia AL @ Grambling | |
| 11/6/2010 | Henderson State @ South Alabama | |
| 11/11/2010 | Arkansas-Monticello @ South Alabama | |
| 11/13/2010 | Kentucky Wesleyan @ Concordia AL | |
| 11/20/2010 | Georgia State @ Alabama |