| 8/28/2010 | Trinity Bible Lions 0 @ Valley City State 44 | |
| 9/11/2010 | Valley City State 0 @ Concordia-Moorhead Cobbers 42 | |
| 9/18/2010 | South Dakota Tech Jackrabbits 24 @ Valley City State 21 | † |
| 9/25/2010 | Valley City State 3 @ Minot State Beavers 34 | † |
| 10/2/2010 | Dickinson State Blue Hawks 16 @ Valley City State 6 | † |
| 10/9/2010 | Valley City State 10 @ Black Hills State Yellow Jackets 31 | † |
| 10/16/2010 | Dakota State Trojans 10 @ Valley City State 54 | † |
| 10/23/2010 | Valley City State 36 @ Mayville State Comets 6 | † |
| 10/30/2010 | Valley City State 13 @ Jamestown Jimmies 19 | † |