| 9/4/2010 | Jacksonville Dolphins 35 @ Old Dominion 25 | |
| 9/11/2010 | Old Dominion 44 @ Campbell Camels 13 | |
| 9/18/2010 | William & Mary Tribe 21 @ Old Dominion 17 | |
| 9/25/2010 | Old Dominion 35 @ Monmouth NJ Hawks 21 | |
| 10/2/2010 | Gardner-Webb Runnin' Bulldogs 7 @ Old Dominion 14 | |
| 10/9/2010 | Cal Poly Mustangs 50 @ Old Dominion 37 | |
| 10/23/2010 | Georgia State Panthers 20 @ Old Dominion 34 | |
| 10/30/2010 | Old Dominion 28 @ Hampton Pirates 14 | |
| 11/6/2010 | Savannah State Tigers 9 @ Old Dominion 57 | † |
| 11/13/2010 | VMI Keydets 28 @ Old Dominion 45 | |
| 11/20/2010 | Old Dominion 33 @ North Carolina Central Eagles 21 | † |