| 9/4/2010 | Pikeville 0 @ South Alabama Jaguars 56 | |
| 9/11/2010 | Pikeville 28 @ Kentucky Wesleyan Panthers 34 | |
| 9/18/2010 | Shorter Hawks 49 @ Pikeville 14 | † |
| 9/25/2010 | Pikeville 36 @ Faulkner Eagles 42 1OT | † |
| 10/2/2010 | Campbellsville Tigers 62 @ Pikeville 17 | † |
| 10/9/2010 | Pikeville 52 @ Lindsey Wilson Blue Raiders 59 | † |
| 10/16/2010 | Pikeville 58 @ Georgetown KY Tigers 70 | † |
| 10/23/2010 | Virginia-Wise Highland Cavaliers 33 @ Pikeville 10 | † |
| 11/6/2010 | West Virginia Tech Golden Bears 36 @ Pikeville 40 | † |
| 11/14/2010 | Kentucky Christian Knights 14 @ Pikeville 44 | † |