| 8/28/2010 | Morehouse Maroon Tigers 34 @ Benedict 27 | † |
| 9/4/2010 | Benedict 18 @ Tuskegee Golden Tigers 34 | † |
| 9/11/2010 | Kentucky State Thorobreds 26 vs Benedict 21 (Augusta GA) | † |
| 9/18/2010 | South Carolina State Bulldogs 61 @ Benedict 20 | |
| 9/25/2010 | Stillman Tigers 0 @ Benedict 35 | † |
| 10/2/2010 | Benedict 13 @ Fort Valley State Wildcats 41 | † |
| 10/9/2010 | Benedict 30 @ Lane Dragons 23 | † |
| 10/16/2010 | Albany State GA Golden Rams 27 @ Benedict 10 | † |
| 10/23/2010 | Benedict 20 @ Miles Golden Bears 14 | † |
| 10/30/2010 | Concordia AL Hornets 14 @ Benedict 41 | |
| 11/6/2010 | Benedict 20 @ Clark Atlanta Panthers 17 | † |