| 9/4/2010 | Savannah State 3 @ Georgia Southern Eagles 48 | |
| 9/11/2010 | Fort Valley State Wildcats 41 vs Savannah State 10 (Macon GA) | |
| 9/18/2010 | Savannah State 7 @ Bethune-Cookman Wildcats 42 | |
| 9/25/2010 | Albany State GA Golden Rams 28 vs Savannah State 14 (Waycross GA) | |
| 10/2/2010 | Savannah State 14 @ Liberty Flames 52 | |
| 10/9/2010 | Savannah State 21 @ Georgia State Panthers 55 | |
| 10/16/2010 | Savannah State 0 @ Florida A&M Rattlers 31 | |
| 10/23/2010 | Savannah State 0 @ Alabama State Hornets 24 | |
| 11/6/2010 | Savannah State 9 @ Old Dominion Monarchs 57 | † |
| 11/13/2010 | North Carolina Central Eagles 21 @ Savannah State 28 | † |
| 11/20/2010 | Norfolk State Spartans 42 @ Savannah State 6 |