| 8/28/2010 | Edward Waters 27 @ Brevard Tornados 53 | |
| 9/4/2010 | Edward Waters 10 @ Bethune-Cookman Wildcats 70 | |
| 9/11/2010 | North Greenville Crusaders 44 @ Edward Waters 14 | |
| 9/25/2010 | Edward Waters 0 vs South Alabama Jaguars 64 (Dothan AL) | |
| 10/16/2010 | Webber International Warriors 45 @ Edward Waters 6 | † |
| 10/23/2010 | Edward Waters 0 @ North Greenville Crusaders 42 | |
| 10/30/2010 | Edward Waters 7 @ North Carolina Central Eagles 20 | |
| 11/6/2010 | Edward Waters 27 @ Lambuth Eagles 44 |