| 9/4/2010 | Louisiana Tech Bulldogs 20 vs Grambling 6 (Shreveport LA) | |
| 9/18/2010 | Jackson State Tigers 21 @ Grambling 28 | † |
| 9/25/2010 | Grambling 34 vs Prairie View Panthers 17 (Dallas TX) | † |
| 10/2/2010 | Grambling 25 @ Alabama A&M Bulldogs 22 | † |
| 10/9/2010 | Alabama State Hornets 7 @ Grambling 22 | † |
| 10/16/2010 | Alcorn State Braves 28 @ Grambling 38 | † |
| 10/23/2010 | Grambling 35 @ Mississippi Valley State Delta Devils 14 | † |
| 10/30/2010 | Grambling 35 vs Ark Pine Bluff Golden Lions 25 (Little Rock AR) | † |
| 11/6/2010 | Concordia AL Hornets 0 @ Grambling 35 | |
| 11/11/2010 | Grambling 34 @ Texas Southern Tigers 41 1OT | † |
| 11/27/2010 | Grambling 38 vs Southern Jaquars 17 (New Orleans LA) | † |