| 9/4/2010 | Waldorf 63 @ Trinity Bible Lions 7 | |
| 9/11/2010 | Briar Cliff Chargers 37 @ Waldorf 7 | |
| 9/18/2010 | Trinity International Trojans 23 @ Waldorf 21 | † |
| 9/25/2010 | Waldorf 0 @ Grand View Vikings 70 | † |
| 10/2/2010 | Waldorf 24 @ Iowa Wesleyan Tigers 30 | † |
| 10/9/2010 | Saint Ambrose Bees 49 @ Waldorf 6 | † |
| 10/16/2010 | McKendree Bearcats 54 @ Waldorf 7 | † |
| 10/23/2010 | Waldorf 21 @ Haskell Indians 10 | |
| 10/30/2010 | Waldorf 10 @ St Francis IL Fighting Saints 56 | † |
| 11/6/2010 | William Penn Statesmen 58 @ Waldorf 10 | † |
| 11/13/2010 | Waldorf 21 @ Quincy Hawks 17 | † |