| 8/28/2010 | Belhaven Blazers 53 @ Texas College 3 | |
| 9/2/2010 | Texas College 0 @ Oauchita Tigers 70 | |
| 9/11/2010 | Texas College 0 @ McMurry 64 | |
| 9/25/2010 | Texas College 20 @ Northwestern Oklahoma State Rangers 79 | † |
| 10/2/2010 | Concordia AL Hornets 17 @ Texas College 13 | |
| 10/16/2010 | Texas College 14 @ Panhandle State Aggies 23 | |
| 10/23/2010 | Southern Nazarene Crimson Storm 52 @ Texas College 49 | † |
| 10/30/2010 | Texas College 6 @ Bacone Warriors 54 | † |
| 11/6/2010 | Langston Lions 45 @ Texas College 0 | † |
| 11/13/2010 | Texas College @ Southwestern Assemblies of God Lions | † |