| 9/4/2010 | Macalester 35 @ Grinnell Pioneers 45 |
| 9/11/2010 | Cornell IA Rams 20 @ Macalester 24 |
| 9/18/2010 | Maranatha Baptist Bible Crusaders 0 @ Macalester 21 |
| 9/25/2010 | Crown Storm 41 @ Macalester 44 |
| 10/2/2010 | Macalester 30 @ Hamline Pipers 49 |
| 10/9/2010 | Trinity Bible Lions 28 @ Macalester 41 |
| 10/23/2010 | Carleton Knights 42 @ Macalester 27 |
| 10/29/2010 | Macalester 48 vs Minnesota-Morris Cougars 27 (Minneapolis MN) |
| 11/6/2010 | Macalester 28 @ Martin Luther Knights 21 |