| 9/4/2010 | Lamar 27 @ McNeese State Cowboys 30 | † |
| 9/11/2010 | Webber International Warriors 14 @ Lamar 21 | |
| 9/18/2010 | Lamar 29 @ Southeastern Louisiana Lions 28 | † |
| 9/25/2010 | Lamar 3 @ Stephen F. Austin Lumberjacks 71 | † |
| 10/2/2010 | Sam Houston Bearkats 38 @ Lamar 10 | † |
| 10/9/2010 | Langston Lions 0 @ Lamar 14 | |
| 10/16/2010 | South Alabama Jaguars 26 @ Lamar 0 | |
| 10/30/2010 | Lamar 6 @ North Dakota Sioux 31 | |
| 11/6/2010 | Lamar 17 @ Georgia State Panthers 23 | |
| 11/13/2010 | South Dakota Coyotes 20 @ Lamar 24 | |
| 11/20/2010 | Panhandle State Aggies 6 @ Lamar 44 |