| 8/27/2022 | Morehead State | 13 | at | Mercer | 63 | @ SoCon | ||
| 9/1/2022 | St Thomas | 13 | at | Southern Utah | 44 | @ WAC | ||
| 9/3/2022 | Presbyterian | 0 | at | Austin Peay | 63 | @ ASUN | ||
| St Thomas FL | 26 | at | Butler | 31 | Sun (NAIA) | |||
| Davidson | 17 | at | Jacksonville State | 35 | @ ASUN | |||
| Georgetown | 43 | at | Marist | 12 | Pat | |||
| Drake | 14 | at | North Dakota State | 56 | @ MVC | |||
| Dayton | 22 | at | Robert Morris | 20 | @ BigS | |||
| La Verne | 0 | at | San Diego | 58 | SCIAC (D3) | |||
| Concordia MI | 14 | at | Stetson | 24 | MSFA (NAIA) | |||
| Indiana Wesleyan | 17 | at | Valparaiso | 20 | MSFA (NAIA) | |||
| 9/10/2022 | Taylor | 10 | at | Butler | 45 | MSFA (NAIA) | ||
| San Diego | 27 | at | Cal Poly | 28 | @ BSky | |||
| Barton | 17 | at | Davidson | 37 | SAC (D2) | |||
| Missouri S&T | 17 | at | Drake | 14 | OT | GLV (D2) | ||
| Valparaiso | 21 | at | Illinois State | 28 | @ MVC | |||
| Morehead State | 13 | at | Montana State | 63 | @ BSky | |||
| Virginia U-Lynchburg | 13 | at | Presbyterian | 21 | None (Unk?) | |||
| Michigan Tech | 6 | at | St Thomas | 32 | GLIAC (D2) | |||
| Louisiana College | 14 | at | Stetson | 45 | Soon (NAIA) | |||
| Dayton | 16 | at | Youngstown State | 49 | @ MVC | |||
| 9/17/2022 | Valparaiso | 13 | at | Dartmouth | 35 | @ Ivy | ||
| St Andrews | 6 | at | Davidson | 56 | MSC (NAIA) | |||
| Kentucky State | 3 | at | Dayton | 46 | SIAC (D2) | |||
| Drake | 14 | at | Idaho | 42 | @ BSky | |||
| Columbia | 38 | at | Marist | 3 | Ivy | |||
| Kentucky Christian | 14 | at | Morehead State | 49 | MSC (NAIA) | |||
| Butler | 17 | at | South Dakota State | 45 | @ MVC | |||
| Princeton | 39 | at | Stetson | 14 | Ivy | |||
| San Diego | 13 | at | UC Davis | 43 | @ BSky | |||
| Presbyterian | 21 | at | Western Carolina | 77 | @ SoCon | |||
| 9/24/2022 | Marist | 30 | at | Drake | 25 | |||
| Davidson | 56 | at | Presbyterian | 24 | ||||
| Lincoln CA | 6 | at | St Thomas | 43 | None (Unk?) | |||
| Morehead State | 26 | at | Stetson | 38 | ||||
| San Diego | 21 | at | Valparaiso | 28 | ||||
| 10/1/2022 | Butler | 0 | at | Davidson | 31 | |||
| Drake | 14 | at | Dayton | 27 | ||||
| St Thomas | 38 | at | Marist | 24 | ||||
| Presbyterian | 10 | at | Morehead State | 14 | ||||
| Stetson | at | San Diego | CCD | |||||
| 10/8/2022 | Dayton | 0 | at | Butler | 31 | |||
| San Diego | 22 | at | Drake | 10 | ||||
| Valparaiso | 41 | at | Presbyterian | 21 | ||||
| Davidson | 16 | at | St Thomas | 27 | ||||
| Marist | 45 | at | Stetson | 31 | ||||
| 10/15/2022 | Morehead State | 26 | at | Davidson | 28 | |||
| Dayton | 24 | at | Marist | 7 | ||||
| Presbyterian | 3 | at | San Diego | 28 | ||||
| Drake | 14 | at | St Thomas | 26 | ||||
| Butler | 26 | at | Valparaiso | 25 | ||||
| 10/22/2022 | Marist | 10 | at | Butler | 31 | |||
| Stetson | 20 | at | Dayton | 23 | ||||
| Davidson | 48 | at | Drake | 14 | ||||
| Valparaiso | 40 | at | Morehead State | 35 | ||||
| St Thomas | 46 | at | Presbyterian | 17 | ||||
| 10/29/2022 | Morehead State | 20 | at | Butler | 56 | |||
| Valparaiso | 24 | at | Dayton | 31 | ||||
| Presbyterian | 7 | at | Marist | 37 | ||||
| San Diego | 42 | at | St Thomas | 49 | ||||
| Drake | 24 | at | Stetson | 17 | ||||
| 11/5/2022 | Stetson | 48 | at | Davidson | 56 | 2OT | ||
| Marist | 31 | at | Morehead State | 21 | ||||
| Dayton | 52 | at | Presbyterian | 28 | ||||
| Butler | 26 | at | San Diego | 23 | ||||
| St Thomas | 34 | at | Valparaiso | 7 | ||||
| 11/12/2022 | Morehead State | 27 | at | Dayton | 49 | |||
| Butler | 24 | at | Drake | 27 | ||||
| Valparaiso | 45 | at | Marist | 24 | ||||
| Davidson | 14 | at | San Diego | 31 | ||||
| Stetson | 0 | at | St Thomas | 23 | ||||
| 11/19/2022 | Marist | 13 | at | Bucknell | 24 | @ Pat | ||
| St Thomas | 27 | at | Butler | 13 | ||||
| Dayton | 23 | at | Davidson | 24 | ||||
| San Diego | 14 | at | Morehead State | 9 | ||||
| Presbyterian | 21 | at | Stetson | 42 | ||||
| Drake | 24 | at | Valparaiso | 0 | ||||
| 11/26/2022 | Davidson | 0 | at | Richmond | 41 | FCS Championship - Round 1 | @ CAAF | |
| 12/3/2022 | Valparaiso | 3 | at | New Mexico State | 65 | @ Ind (1A) |