| 9/1/2022 | Cal Poly | 7 | at | Fresno State (10-4) | 35 | at MW | ||
| 9/10/2022 | San Diego (5-5) | 27 | at | Cal Poly | 28 | Pio | ||
| 9/17/2022 | Cal Poly | 21 | at | South Dakota (3-8) | 38 | at MVC | ||
| 10/1/2022 | Sacramento State (12-1,8-0) | 49 | at | Cal Poly | 21 | |||
| 10/8/2022 | Cal Poly | 29 | at | Northern Arizona (3-8,2-6) | 31 | |||
| 10/15/2022 | Cal Poly | 31 | at | Idaho State (1-10,1-7) | 40 | |||
| 10/22/2022 | Eastern Washington (3-8,2-6) | 17 | at | Cal Poly | 10 | |||
| 10/29/2022 | Cal Poly | 17 | at | UC Davis (6-5,5-3) | 59 | |||
| 11/5/2022 | Cal Poly | 0 | at | Montana (8-5,4-4) | 57 | |||
| 11/12/2022 | Montana State (12-2,9-0) | 72 | at | Cal Poly | 28 | |||
| 11/19/2022 | Portland State (4-7,3-5) | 42 | at | Cal Poly | 49 |
| vs Cal Poly | vs Other Opponents | Cal Poly compared to OOs | |
| Record: | 9-2 | 58-61 | |
| Points Scored: | 42.45 | 28.50 | -13.95 |
| Points Allowed: | 21.91 | 28.45 | -6.54 |
| Margin: | 20.54 | 0.05 | -20.49 |
| Total Points: | 64.36 | 56.95 | 7.41 |