| 9/3/2022 | Duquesne (4-7) | 14 | at | Youngstown State | 31 | NE | ||
| 9/10/2022 | Dayton (8-3) | 16 | at | Youngstown State | 49 | Pio | ||
| 9/17/2022 | Youngstown State | 0 | at | Kentucky (7-6) | 31 | at SEC | ||
| 10/1/2022 | Youngstown State | 14 | at | North Dakota State (12-3,7-2) | 27 | |||
| 10/8/2022 | North Dakota (7-5,5-3) | 35 | at | Youngstown State | 30 | |||
| 10/15/2022 | Indiana State (2-9,1-7) | 42 | at | Youngstown State | 48 | |||
| 10/22/2022 | Youngstown State | 28 | at | Western Illinois (0-11,0-8) | 27 | |||
| 10/29/2022 | South Dakota (3-8,2-6) | 24 | at | Youngstown State | 45 | |||
| 11/5/2022 | Youngstown State | 19 | at | Illinois State (6-5,4-4) | 17 | |||
| 11/12/2022 | Youngstown State | 22 | at | Missouri State (5-6,3-5) | 25 | |||
| 11/19/2022 | Southern Illinois (5-6,4-4) | 21 | at | Youngstown State | 28 |
| vs Youngstown State | vs Other Opponents | Youngstown State compared to OOs | |
| Record: | 4-7 | 55-62 | |
| Points Scored: | 25.36 | 23.55 | -1.81 |
| Points Allowed: | 28.55 | 26.36 | 2.19 |
| Margin: | -3.19 | -2.81 | 0.38 |
| Total Points: | 53.91 | 49.91 | 4.00 |