| 9/1/2022 | South Dakota Tech (7-4) | 43 | at | Missouri S&T | 20 | RMAC | ||
| 9/10/2022 | Missouri S&T | 17 | at | Drake (3-8) | 14 | OT | at Pio | |
| 9/17/2022 | Missouri S&T | 6 | at | Kentucky Wesleyan (2-9) | 11 | at GMAC | ||
| 9/24/2022 | Hillsdale (5-6) | 17 | at | Missouri S&T | 10 | GMAC | ||
| 10/1/2022 | Quincy (4-7,1-5) | 24 | at | Missouri S&T | 31 | |||
| 10/8/2022 | Missouri S&T | 14 | at | Truman State (9-2,5-1) | 36 | |||
| 10/15/2022 | Missouri S&T | 41 | at | William Jewell (2-9,1-5) | 14 | |||
| 10/22/2022 | McKendree (5-6,2-4) | 42 | at | Missouri S&T | 35 | |||
| 10/29/2022 | Missouri S&T | 16 | at | Indianapolis (9-2,6-0) | 42 | |||
| 11/12/2022 | Southwest Baptist (6-5,4-2) | 24 | at | Missouri S&T | 17 |
| vs Missouri S&T | vs Other Opponents | Missouri S&T compared to OOs | |
| Record: | 7-3 | 45-55 | |
| Points Scored: | 26.70 | 27.05 | 0.35 |
| Points Allowed: | 20.70 | 31.06 | -10.36 |
| Margin: | 6.00 | -4.01 | -10.01 |
| Total Points: | 47.40 | 58.11 | -10.71 |