| 9/3/2022 | Indiana Wesleyan | 17 | at | Valparaiso (5-7) | 20 | at Pio | ||
| 9/17/2022 | Indiana Wesleyan | 34 | at | Olivet Nazarene (7-4,6-4) | 26 | |||
| 9/24/2022 | Trinity International (1-10,1-8) | 6 | at | Indiana Wesleyan | 63 | |||
| 10/1/2022 | Concordia MI (5-5,5-4) | 13 | at | Indiana Wesleyan | 23 | |||
| 10/8/2022 | Indiana Wesleyan | 17 | at | Marian IN (9-2,9-1) | 10 | |||
| 10/15/2022 | Indiana Wesleyan | 35 | at | Lawrence Tech (3-7,3-6) | 14 | |||
| 10/22/2022 | St Francis IN (4-6,4-6) | 0 | at | Indiana Wesleyan | 44 | |||
| 10/29/2022 | Indiana Wesleyan | 22 | at | Siena Heights (5-5,5-5) | 6 | |||
| 11/5/2022 | Taylor (5-6,5-5) | 20 | at | Indiana Wesleyan | 61 | |||
| 11/12/2022 | Madonna (0-11,0-9) | 7 | at | Indiana Wesleyan | 79 | |||
| 11/19/2022 | Avila (10-2) | 7 | at | Indiana Wesleyan | 14 | NAIA Championship Round 1 | KCAC | |
| 12/3/2022 | Indiana Wesleyan | 7 | at | Northwestern IA (13-1) | 38 | NAIA Semifinals | at GPAC |
| vs Indiana Wesleyan | vs Other Opponents | Indiana Wesleyan compared to OOs | |
| Record: | 2-10 | 65-56 | |
| Points Scored: | 13.92 | 27.80 | 13.88 |
| Points Allowed: | 34.67 | 24.62 | 10.05 |
| Margin: | -20.75 | 3.18 | 23.93 |
| Total Points: | 48.59 | 52.42 | -3.83 |