| 9/3/2022 | Louisiana College | 0 | at | Southwestern Assemblies of God (7-4,6-3) | 27 | |||
| 9/10/2022 | Louisiana College | 14 | at | Stetson (4-6) | 45 | at Pio | ||
| 9/17/2022 | Arizona Christian (8-3,7-2) | 26 | at | Louisiana College | 40 | |||
| 9/24/2022 | Louisiana College | 13 | at | Ottawa AZ (7-2,7-2) | 45 | |||
| 10/1/2022 | Louisiana College | 16 | at | Panhandle State (4-6,4-5) | 28 | |||
| 10/8/2022 | Arkansas Baptist (1-7) | 14 | at | Louisiana College | 42 | None (Unk?) | ||
| 10/15/2022 | Wayland Baptist (2-8,2-7) | 17 | at | Louisiana College | 37 | |||
| 10/22/2022 | Texas Wesleyan (8-2,7-2) | 9 | at | Louisiana College | 33 | |||
| 10/29/2022 | Louisiana College | 39 | at | Langston (6-4,5-4) | 14 | |||
| 11/5/2022 | Lyon (1-9,0-9) | 3 | at | Louisiana College | 50 | |||
| 11/12/2022 | Louisiana College | 56 | at | Texas College (1-9,1-8) | 6 |
| vs Louisiana College | vs Other Opponents | Louisiana College compared to OOs | |
| Record: | 4-7 | 45-53 | |
| Points Scored: | 21.27 | 28.91 | 7.64 |
| Points Allowed: | 30.91 | 31.20 | -0.29 |
| Margin: | -9.64 | -2.29 | 7.35 |
| Total Points: | 52.18 | 60.11 | -7.93 |