| 9/2/2010 | Hampton @ Central Michigan | |
| 9/2/2010 | Florida A&M @ Miami-Florida | |
| 9/2/2010 | Norfolk State @ Rutgers | |
| 9/4/2010 | Edward Waters @ Bethune-Cookman | |
| 9/4/2010 | South Carolina State @ Georgia Tech | |
| 9/4/2010 | Howard @ Holy Cross | |
| 9/4/2010 | Bowie State @ Morgan State | |
| 9/4/2010 | Winston-Salem State @ North Carolina A&T | |
| 9/5/2010 | Delaware State vs Southern | |
| 9/11/2010 | Florida A&M @ Delaware State | † |
| 9/11/2010 | Hampton @ Howard | † |
| 9/11/2010 | Morgan State @ Maryland | |
| 9/11/2010 | North Carolina A&T @ Norfolk State | † |
| 9/11/2010 | Mississippi Valley State @ South Carolina State | |
| 9/18/2010 | South Carolina State @ Benedict | |
| 9/18/2010 | Savannah State @ Bethune-Cookman | |
| 9/18/2010 | North Carolina A&T @ Hampton | † |
| 9/18/2010 | Florida A&M @ Howard | † |
| 9/18/2010 | Virginia State @ Norfolk State | |
| 9/18/2010 | Morgan State @ North Dakota State | |
| 9/25/2010 | Norfolk State @ Bethune-Cookman | † |
| 9/25/2010 | Delaware State @ Coastal Carolina | |
| 9/25/2010 | Howard vs Morgan State | † |
| 9/25/2010 | North Carolina A&T @ North Carolina Central | |
| 9/25/2010 | Florida A&M vs Tennessee State | |
| 10/2/2010 | Hampton @ Delaware State | † |
| 10/2/2010 | South Carolina State @ Florida A&M | † |
| 10/2/2010 | Lincoln PA @ Howard | |
| 10/2/2010 | Bethune-Cookman @ Morgan State | † |
| 10/2/2010 | North Carolina A&T vs Tennessee State | |
| 10/9/2010 | Delaware State @ Bethune-Cookman | † |
| 10/9/2010 | Howard @ Furman | |
| 10/9/2010 | Morgan State @ North Carolina A&T | † |
| 10/9/2010 | Hampton @ North Carolina Central | |
| 10/9/2010 | Norfolk State @ South Carolina State | † |
| 10/16/2010 | North Carolina A&T @ Delaware State | † |
| 10/16/2010 | Savannah State @ Florida A&M | |
| 10/16/2010 | Norfolk State @ Hampton | † |
| 10/16/2010 | Bethune-Cookman @ South Carolina State | † |
| 10/23/2010 | Delaware State @ Morgan State | † |
| 10/23/2010 | Florida A&M @ Norfolk State | † |
| 10/23/2010 | Howard @ North Carolina A&T | † |
| 10/23/2010 | Bethune-Cookman @ North Carolina Central | |
| 10/23/2010 | Hampton @ South Carolina State | † |
| 10/30/2010 | North Carolina A&T @ Bethune-Cookman | † |
| 10/30/2010 | South Carolina State @ Delaware State | † |
| 10/30/2010 | Morgan State @ Florida A&M | † |
| 10/30/2010 | Old Dominion @ Hampton | |
| 10/30/2010 | Norfolk State @ Howard | † |
| 11/6/2010 | North Carolina Central @ Delaware State | |
| 11/6/2010 | Bethune-Cookman @ Hampton | † |
| 11/6/2010 | Morgan State @ Norfolk State | † |
| 11/6/2010 | Florida A&M @ North Carolina A&T | † |
| 11/6/2010 | Howard @ South Carolina State | † |
| 11/13/2010 | Howard @ Bethune-Cookman | † |
| 11/13/2010 | Hampton @ Florida A&M | † |
| 11/13/2010 | South Carolina State @ Morgan State | † |
| 11/13/2010 | Delaware State @ Norfolk State | † |
| 11/20/2010 | Florida A&M vs Bethune-Cookman | † |
| 11/20/2010 | Delaware State @ Howard | † |
| 11/20/2010 | Hampton @ Morgan State | † |
| 11/20/2010 | South Carolina State @ North Carolina A&T | † |
| 11/20/2010 | Norfolk State @ Savannah State |