| 9/4/2010 | Coastal Carolina 0 @ West Virginia Mountaineers 31 | |
| 9/11/2010 | Coastal Carolina 45 @ Towson Tigers 47 | |
| 9/18/2010 | Georgia Southern Eagles 43 @ Coastal Carolina 26 | |
| 9/25/2010 | Delaware State Hornets 14 @ Coastal Carolina 34 | |
| 10/2/2010 | Coastal Carolina 19 @ Richmond Spiders 41 | |
| 10/16/2010 | Coastal Carolina 35 @ Presbyterian Blue Hose 7 | † |
| 10/23/2010 | Stony Brook Seawolves 38 @ Coastal Carolina 28 | † |
| 10/30/2010 | Coastal Carolina 30 @ Gardner-Webb Runnin' Bulldogs 27 1OT | † |
| 11/6/2010 | Coastal Carolina 31 @ VMI Keydets 3 | † |
| 11/13/2010 | Liberty Flames 31 @ Coastal Carolina 45 | † |
| 11/20/2010 | Charleston Southern Buccaneers 3 @ Coastal Carolina 70 | † |
| 11/27/2010 | Western Illinois Leathernecks 17 @ Coastal Carolina 10 (FBS Playoffs) |