Mississippi Valley State Delta Devils

0-10 (0-9 Southwestern Athletic)

9/4/2010 Mississippi Valley State 6 @ Alabama State Hornets 34 †
9/11/2010 Mississippi Valley State 0 @ South Carolina State Bulldogs 44
9/18/2010 Alcorn State Braves 27 @ Mississippi Valley State 9 †
9/25/2010 Mississippi Valley State 7 @ Jackson State Tigers 43 †
10/2/2010 Prairie View Panthers 34 @ Mississippi Valley State 13 †
10/9/2010 Mississippi Valley State 20 @ Southern Jaquars 38 †
10/23/2010 Grambling Tigers 35 @ Mississippi Valley State 14 †
10/30/2010 Mississippi Valley State 7 @ Texas Southern Tigers 38 †
11/6/2010 Mississippi Valley State 20 @ Ark Pine Bluff Golden Lions 49 †
11/13/2010 Alabama A&M Bulldogs 21 @ Mississippi Valley State 7 †