| 9/2/2010 | Florida A&M Rattlers 0 @ Miami-Florida 45 | |
| 9/11/2010 | Miami-Florida 24 @ Ohio State Buckeyes 36 | |
| 9/23/2010 | Miami-Florida 31 @ Pittsburgh Panthers 3 | |
| 10/2/2010 | Miami-Florida 30 @ Clemson Tigers 21 | † |
| 10/9/2010 | Florida State Seminoles 45 @ Miami-Florida 17 | † |
| 10/16/2010 | Miami-Florida 28 @ Duke Blue Devils 13 | † |
| 10/23/2010 | North Carolina Tar Heels 10 @ Miami-Florida 33 | † |
| 10/30/2010 | Miami-Florida 19 @ Virginia Cavaliers 24 | † |
| 11/6/2010 | Maryland Terrapins 20 @ Miami-Florida 26 | † |
| 11/13/2010 | Miami-Florida 35 @ Georgia Tech Yellow Jackets 10 | † |
| 11/20/2010 | Virginia Tech Hokies 31 @ Miami-Florida 17 | † |
| 11/27/2010 | South Florida Bulls 23 @ Miami-Florida 20 1OT | |
| 12/31/2010 | Notre Dame Fighting Irish 33 vs Miami-Florida 17 (El Paso - Sun Bowl) |