| 9/4/2010 | Alabama A&M Bulldogs 14 @ Tennessee State 27 | |
| 9/11/2010 | Jackson State Tigers 33 vs Tennessee State 26 (Memphis TN) | |
| 9/18/2010 | Austin Peay Governers 26 @ Tennessee State 23 | † |
| 9/25/2010 | Florida A&M Rattlers 18 vs Tennessee State 29 (Atlanta GA) | |
| 10/2/2010 | North Carolina A&T Aggies 7 vs Tennessee State 37 (Indianapolis IN) | |
| 10/9/2010 | Tennessee State 17 @ SE Missouri State Redhawks 19 | † |
| 10/16/2010 | Tennessee State 0 @ Jacksonville State Gamecocks 24 | † |
| 10/23/2010 | Tennessee Tech Golden Eagles 21 @ Tennessee State 10 | † |
| 11/6/2010 | Eastern Illinois Panthers 31 @ Tennessee State 28 1OT | † |
| 11/13/2010 | Tennessee State 0 @ Tennessee-Martin Skyhawks 37 | † |
| 11/20/2010 | Tennessee State 23 @ Murray State Racers 28 | † |