| 9/1/2022 | Central Washington | 20 | at | Ferris State | 36 | LSC | ||
| Colorado Mines | 22 | at | Grand Valley State | 25 | RMAC | |||
| Wisconsin-Platteville | 13 | at | Michigan Tech | 23 | WIAC (D3) | |||
| McKendree | 31 | at | Northern Michigan | 24 | OT | GLV | ||
| West Virginia Wesleyan | 0 | at | Saginaw Valley State | 72 | MtnE | |||
| 9/3/2022 | Wayne State MI | 10 | at | Slippery Rock | 42 | @ PSAC | ||
| Davenport | 20 | at | Truman State | 19 | @ GLV | |||
| 9/10/2022 | Grand Valley State | 35 | at | Colorado State-Pueblo | 10 | @ RMAC | ||
| Ferris State | 27 | at | Lenoir-Rhyne | 5 | @ SAC | |||
| Wisconsin-Oshkosh | 10 | at | Northern Michigan | 13 | WIAC (D3) | |||
| Bowie State | 12 | at | Saginaw Valley State | 40 | CIAA | |||
| Michigan Tech | 6 | at | St Thomas | 32 | @ Pio (1AA) | |||
| Shaw | 22 | at | Wayne State MI | 30 | CIAA | |||
| 9/17/2022 | Northern Michigan | 21 | at | Davenport | 31 | |||
| Lincoln CA | 7 | at | Grand Valley State | 66 | None (Unk?) | |||
| Michigan Tech | 21 | at | Midwestern State | 28 | @ LSC | |||
| Saginaw Valley State | 35 | at | Northwood | 14 | @ GMAC | |||
| Wisconsin-La Crosse | 28 | at | Wayne State MI | 21 | WIAC (D3) | |||
| 9/24/2022 | Northwood | 17 | at | Davenport | 51 | GMAC | ||
| Waldorf | 3 | at | Ferris State | 69 | NSAA (NAIA) | |||
| Saginaw Valley State | 35 | at | Michigan Tech | 13 | ||||
| Post | 14 | at | Northern Michigan | 42 | D2Ind | |||
| Grand Valley State | 48 | at | Wayne State MI | 9 | ||||
| 10/1/2022 | Michigan Tech | 38 | at | Davenport | 52 | |||
| Ferris State | 38 | at | Findlay | 7 | @ GMAC | |||
| Saginaw Valley State | 10 | at | Grand Valley State | 29 | ||||
| Northern Michigan | 37 | at | Wayne State MI | 30 | ||||
| 10/8/2022 | Grand Valley State | 45 | at | American Int'l | 3 | @ NE10 | ||
| Wayne State MI | 34 | at | Michigan Tech | 35 | ||||
| Davenport | 27 | at | Northern Michigan | 24 | OT | |||
| Ferris State | 33 | at | Saginaw Valley State | 28 | ||||
| 10/15/2022 | Wayne State MI | 43 | at | Davenport | 47 | |||
| Grand Valley State | 22 | at | Ferris State | 21 | ||||
| Northern Michigan | 7 | at | Michigan Tech | 21 | ||||
| Indianapolis | 14 | at | Saginaw Valley State | 38 | GLV | |||
| 10/22/2022 | Lincoln CA | 14 | at | Davenport | 58 | None (Unk?) | ||
| Michigan Tech | 20 | at | Ferris State | 28 | ||||
| Northern Michigan | 3 | at | Grand Valley State | 56 | ||||
| Saginaw Valley State | 21 | at | Wayne State MI | 14 | ||||
| 10/29/2022 | Grand Valley State | 42 | at | Michigan Tech | 7 | |||
| Ferris State | 56 | at | Northern Michigan | 20 | ||||
| Davenport | 29 | at | Saginaw Valley State | 28 | ||||
| 11/5/2022 | Davenport | 7 | at | Ferris State | 28 | |||
| Wayne State MI | 14 | at | Grand Valley State | 42 | ||||
| Michigan Tech | 28 | at | Hillsdale | 24 | @ GMAC | |||
| Saginaw Valley State | 30 | at | Northern Michigan | 21 | ||||
| 11/12/2022 | Grand Valley State | 49 | at | Davenport | 7 | |||
| Northern Michigan | 33 | at | Lake Erie | 11 | @ GMAC | |||
| Michigan Tech | 30 | at | Saginaw Valley State | 35 | ||||
| Ferris State | 40 | at | Wayne State MI | 14 | ||||
| 11/19/2022 | Davenport | 7 | at | Ferris State | 41 | D2 Championship Round 1 | ||
| 11/26/2022 | Pittsburg State | 14 | at | Ferris State | 17 | D2 Playoffs Round 2 | MAIAA | |
| Northwest Missouri State | 8 | at | Grand Valley State | 13 | D2 Playoffs Round 2 | MAIAA | ||
| 12/3/2022 | Ferris State | 24 | at | Grand Valley State | 21 | D2 Quarterfinals | ||
| 12/10/2022 | West Florida | 17 | at | Ferris State | 38 | D2 Semifinal | GSC | |
| 12/17/2022 | Colorado Mines | 14 | vs | Ferris State | 41 | D2 Championship - Mckinney TX | vs RMAC |