| 9/3/2022 | Kentucky Wesleyan (2-9,1-7) | 13 | at | Northwood | 55 | |||
| 9/10/2022 | Madonna (0-11) | 0 | at | Northwood | 38 | MSFA (NAIA) | ||
| 9/17/2022 | Saginaw Valley State (8-3) | 35 | at | Northwood | 14 | GLIAC | ||
| 9/24/2022 | Northwood | 17 | at | Davenport (8-3) | 51 | at GLIAC | ||
| 10/1/2022 | Northwood | 17 | at | Ashland (10-2,7-1) | 56 | |||
| 10/8/2022 | Northwood | 14 | at | Findlay (7-4,6-2) | 34 | |||
| 10/15/2022 | Hillsdale (5-6,4-4) | 41 | at | Northwood | 7 | |||
| 10/22/2022 | Northwood | 18 | at | Lake Erie (3-8,3-5) | 21 | |||
| 10/29/2022 | Northwood | 3 | at | Tiffin (6-5,6-2) | 48 | |||
| 11/5/2022 | Ohio Dominican (7-3,6-2) | 35 | at | Northwood | 24 | |||
| 11/12/2022 | Walsh (1-9,1-7) | 14 | at | Northwood | 34 |
| vs Northwood | vs Other Opponents | Northwood compared to OOs | |
| Record: | 8-3 | 49-60 | |
| Points Scored: | 31.64 | 23.76 | -7.88 |
| Points Allowed: | 21.91 | 27.61 | -5.70 |
| Margin: | 9.73 | -3.85 | -13.58 |
| Total Points: | 53.55 | 51.37 | 2.18 |