| 9/1/2022 | Colorado Mines | 22 | at | Grand Valley State (12-1) | 25 | | | at GLIAC |
| 9/10/2022 | Angelo State (12-1) | 30 | at | Colorado Mines | 27 | OT | | LSC |
| 9/17/2022 | Colorado Mines | 84 | at | Adams State (2-9,2-7) | 10 | | | |
| 9/24/2022 | Colorado State-Pueblo (8-4,7-3) | 17 | at | Colorado Mines | 45 | | | |
| 10/1/2022 | Colorado Mines | 45 | at | Chadron State (3-8,3-6) | 9 | | | |
| 10/8/2022 | Colorado Mesa (4-6,3-6) | 21 | at | Colorado Mines | 48 | | | |
| 10/15/2022 | Colorado Mines | 48 | at | South Dakota Tech (7-4,6-3) | 20 | | | |
| 10/22/2022 | Black Hills State (7-4,5-4) | 0 | at | Colorado Mines | 38 | | | |
| 10/29/2022 | Colorado Mines | 30 | at | Western Colorado (7-4,7-2) | 20 | | | |
| 11/5/2022 | Colorado Mines | 54 | at | New Mexico Highlands (3-7,3-6) | 16 | | | |
| 11/12/2022 | Fort Lewis (0-10,0-9) | 0 | at | Colorado Mines | 80 | | | |
| 11/19/2022 | Colorado State-Pueblo (8-4,7-3) | 24 | at | Colorado Mines | 45 | | D2 Championship Round 1 | |
| 11/26/2022 | Minnesota State-Mankato (10-3) | 45 | at | Colorado Mines | 48 | | D2 Playoffs Round 2 | NSIC |
| 12/3/2022 | Colorado Mines | 42 | at | Angelo State (12-1) | 24 | | D2 Quarterfinals | at LSC |
| 12/10/2022 | Shepherd (13-2) | 13 | at | Colorado Mines | 44 | | D2 Semifinal | PSAC |
| 12/17/2022 | Colorado Mines | 14 | vs | Ferris State (14-1) | 41 | | D2 Championship - Mckinney TX | vs GLIAC |