| 9/1/2022 | Fort Hays State (3-8,3-8) | 19 | at | Northwest Missouri State | 33 | | | |
| 9/10/2022 | Northwest Missouri State | 58 | at | Lincoln MO (0-11,0-11) | 20 | | | |
| 9/17/2022 | Central Missouri (4-7,4-7) | 7 | at | Northwest Missouri State | 24 | | | |
| 9/24/2022 | Northwest Missouri State | 14 | at | Central Oklahoma (6-5,6-5) | 23 | | | |
| 10/1/2022 | Missouri Western (5-6,5-6) | 3 | at | Northwest Missouri State | 16 | | | |
| 10/8/2022 | Northwest Missouri State | 22 | at | Pittsburg State (12-1,11-0) | 24 | | | |
| 10/15/2022 | Washburn (7-4,7-4) | 30 | at | Northwest Missouri State | 32 | | | |
| 10/22/2022 | Northeastern State (1-10,1-10) | 3 | at | Northwest Missouri State | 36 | | | |
| 10/29/2022 | Northwest Missouri State | 28 | at | Nebraska-Kearney (8-3,8-3) | 24 | | | |
| 11/5/2022 | Missouri Southern (4-7,4-7) | 5 | at | Northwest Missouri State | 27 | | | |
| 11/12/2022 | Northwest Missouri State | 27 | at | Emporia State (9-3,8-3) | 21 | | | |
| 11/19/2022 | Northwest Missouri State | 47 | at | Ouachita (11-1) | 17 | | D2 Championship Round 1 | at GAC |
| 11/26/2022 | Northwest Missouri State | 8 | at | Grand Valley State (12-1) | 13 | | D2 Playoffs Round 2 | at GLIAC |