| 9/3/2022 | Wingate (11-3) | 21 | at | Shaw | 7 | SAC | ||
| 9/10/2022 | Shaw | 22 | at | Wayne State MI (1-9) | 30 | at GLIAC | ||
| 9/17/2022 | Bowie State (6-4,5-3) | 14 | at | Shaw | 17 | |||
| 9/24/2022 | Elizabeth City State (2-8,2-7) | 16 | at | Shaw | 35 | |||
| 10/1/2022 | Shaw | 24 | at | Virginia State (6-4,5-3) | 28 | |||
| 10/8/2022 | Shaw | 18 | at | Johnson C Smith (2-7,2-6) | 22 | |||
| 10/15/2022 | Shaw | 10 | at | Winston-Salem State (3-6,3-4) | 17 | |||
| 10/22/2022 | Livingstone (4-6,4-5) | 14 | at | Shaw | 28 | |||
| 10/29/2022 | Shaw | 20 | at | Fayetteville State (9-3,8-1) | 28 | |||
| 11/5/2022 | St Augustine's (1-9,1-7) | 27 | at | Shaw | 30 |
| vs Shaw | vs Other Opponents | Shaw compared to OOs | |
| Record: | 6-4 | 39-55 | |
| Points Scored: | 21.70 | 21.33 | -0.37 |
| Points Allowed: | 21.10 | 26.82 | -5.72 |
| Margin: | 0.60 | -5.49 | -6.09 |
| Total Points: | 42.80 | 48.15 | -5.35 |