| 9/3/2022 | Wayne State MI (1-9) | 10 | at | Slippery Rock | 42 | GLIAC | ||
| 9/10/2022 | Slippery Rock | 35 | at | West Chester (7-4,6-4) | 14 | |||
| 9/17/2022 | Slippery Rock | 45 | at | Millersville (5-6,5-5) | 14 | |||
| 9/24/2022 | Seton Hill (2-9,2-8) | 2 | at | Slippery Rock | 30 | |||
| 10/1/2022 | Slippery Rock | 12 | at | Indiana PA (10-2,9-2) | 20 | |||
| 10/8/2022 | Mercyhurst (2-9,1-9) | 17 | at | Slippery Rock | 31 | |||
| 10/15/2022 | Gannon (8-3,7-3) | 14 | at | Slippery Rock | 40 | |||
| 10/22/2022 | Slippery Rock | 42 | at | California PA (6-5,5-5) | 24 | |||
| 10/29/2022 | Slippery Rock | 31 | at | Clarion (3-8,3-7) | 0 | |||
| 11/5/2022 | Edinboro (5-6,4-6) | 21 | at | Slippery Rock | 28 | |||
| 11/12/2022 | Kutztown (8-3,8-2) | 23 | at | Slippery Rock | 21 | |||
| 11/19/2022 | Slippery Rock | 17 | at | Assumption (8-3) | 14 | D2 Championship Round 1 | at NE10 | |
| 11/26/2022 | Slippery Rock | 27 | at | Shepherd (13-2,11-1) | 37 | D2 Playoffs Round 2 |
| vs Slippery Rock | vs Other Opponents | Slippery Rock compared to OOs | |
| Record: | 3-10 | 75-59 | |
| Points Scored: | 16.15 | 25.57 | 9.42 |
| Points Allowed: | 30.85 | 22.63 | 8.22 |
| Margin: | -14.70 | 2.94 | 17.64 |
| Total Points: | 47.00 | 48.20 | -1.20 |