| 9/3/2022 | St Xavier (9-3) | 0 | at | Indianapolis | 57 | MSFA (NAIA) | ||
| 9/17/2022 | Indianapolis | 27 | at | Tiffin (6-5) | 20 | at GMAC | ||
| 9/24/2022 | Indianapolis | 44 | at | Ohio Dominican (7-3) | 38 | at GMAC | ||
| 10/1/2022 | Southwest Baptist (6-5,4-2) | 17 | at | Indianapolis | 44 | |||
| 10/8/2022 | Indianapolis | 38 | at | McKendree (5-6,2-4) | 23 | |||
| 10/15/2022 | Indianapolis | 14 | at | Saginaw Valley State (8-3) | 38 | at GLIAC | ||
| 10/22/2022 | Quincy (4-7,1-5) | 38 | at | Indianapolis | 52 | |||
| 10/29/2022 | Missouri S&T (3-7,2-4) | 16 | at | Indianapolis | 42 | |||
| 11/5/2022 | Indianapolis | 48 | at | William Jewell (2-9,1-5) | 14 | |||
| 11/12/2022 | Truman State (9-2,5-1) | 14 | at | Indianapolis | 28 | |||
| 11/19/2022 | Indianapolis | 0 | at | Pittsburg State (12-1) | 35 | D2 Championship Round 1 | at MAIAA |
| vs Indianapolis | vs Other Opponents | Indianapolis compared to OOs | |
| Record: | 2-9 | 69-42 | |
| Points Scored: | 23.00 | 29.94 | 6.94 |
| Points Allowed: | 35.82 | 24.07 | 11.75 |
| Margin: | -12.82 | 5.87 | 18.69 |
| Total Points: | 58.82 | 54.01 | 4.81 |