| 9/3/2022 | Virginia State (6-4) | 19 | at | Lenoir-Rhyne | 38 | CIAA | ||
| 9/10/2022 | Ferris State (14-1) | 27 | at | Lenoir-Rhyne | 5 | GLIAC | ||
| 9/17/2022 | Lenoir-Rhyne | 42 | at | Erskine (2-9,0-9) | 20 | |||
| 9/24/2022 | Carson-Newman (6-5,5-4) | 13 | at | Lenoir-Rhyne | 34 | |||
| 9/30/2022 | Lenoir-Rhyne | 42 | at | Virginia-Wise (2-9,1-8) | 10 | |||
| 10/8/2022 | Limestone (8-4,7-2) | 30 | at | Lenoir-Rhyne | 51 | |||
| 10/15/2022 | Lenoir-Rhyne | 34 | at | Barton (4-7,3-6) | 0 | |||
| 10/22/2022 | Newberry (9-2,7-2) | 38 | at | Lenoir-Rhyne | 24 | |||
| 10/29/2022 | Wingate (11-3,7-2) | 24 | at | Lenoir-Rhyne | 21 | |||
| 11/5/2022 | Lenoir-Rhyne | 62 | at | Catawba (1-10,0-9) | 10 | |||
| 11/12/2022 | Tusculum (8-3,6-3) | 14 | at | Lenoir-Rhyne | 34 |
| vs Lenoir-Rhyne | vs Other Opponents | Lenoir-Rhyne compared to OOs | |
| Record: | 3-8 | 68-49 | |
| Points Scored: | 18.64 | 27.33 | 8.69 |
| Points Allowed: | 35.18 | 23.32 | 11.86 |
| Margin: | -16.54 | 4.01 | 20.55 |
| Total Points: | 53.82 | 50.65 | 3.17 |