| 9/3/2022 | Colorado State-Pueblo (8-4) | 59 | at | Midwestern State | 27 | RMAC | ||
| 9/10/2022 | Midwestern State | 28 | at | Eastern New Mexico (3-8,2-7) | 14 | |||
| 9/17/2022 | Michigan Tech (4-7) | 21 | at | Midwestern State | 28 | GLIAC | ||
| 9/24/2022 | Simon Fraser (1-8,1-8) | 0 | at | Midwestern State | 77 | |||
| 10/1/2022 | Midwestern State | 27 | at | Western New Mexico (6-5,5-4) | 30 | |||
| 10/8/2022 | West Texas A&M (5-6,3-6) | 38 | at | Midwestern State | 26 | |||
| 10/15/2022 | Midwestern State | 10 | at | Central Washington (6-4,6-3) | 17 | |||
| 10/22/2022 | Midwestern State | 24 | at | Texas-Permian Basin (5-6,4-5) | 23 | |||
| 10/29/2022 | Western Oregon (6-5,5-4) | 21 | at | Midwestern State | 26 | |||
| 11/5/2022 | Midwestern State | 41 | at | Texas A&M-Kingsville (7-5,5-4) | 37 | |||
| 11/12/2022 | Angelo State (12-1,9-0) | 37 | at | Midwestern State | 19 |
| vs Midwestern State | vs Other Opponents | Midwestern State compared to OOs | |
| Record: | 5-6 | 58-53 | |
| Points Scored: | 27.00 | 26.05 | -0.95 |
| Points Allowed: | 30.27 | 24.74 | 5.53 |
| Margin: | -3.27 | 1.31 | 4.58 |
| Total Points: | 57.27 | 50.79 | 6.48 |