| 9/3/2022 | Davenport (8-3) | 20 | at | Truman State | 19 | GLIAC | ||
| 9/10/2022 | Truman State | 27 | at | South Dakota Tech (7-4) | 20 | at RMAC | ||
| 9/17/2022 | Truman State | 21 | at | Hillsdale (5-6) | 13 | at GMAC | ||
| 9/24/2022 | Tiffin (6-5) | 17 | at | Truman State | 18 | OT | GMAC | |
| 10/8/2022 | Missouri S&T (3-7,2-4) | 14 | at | Truman State | 36 | |||
| 10/15/2022 | Southwest Baptist (6-5,4-2) | 20 | at | Truman State | 25 | |||
| 10/22/2022 | Truman State | 42 | at | William Jewell (2-9,1-5) | 7 | |||
| 10/29/2022 | Truman State | 59 | at | Quincy (4-7,1-5) | 32 | |||
| 11/5/2022 | McKendree (5-6,2-4) | 7 | at | Truman State | 52 | |||
| 11/12/2022 | Truman State | 14 | at | Indianapolis (9-2,6-0) | 28 | |||
| 12/3/2022 | Tiffin (6-5) | 27 | vs | Truman State | 28 | Hobart IN | GMAC |
| vs Truman State | vs Other Opponents | Truman State compared to OOs | |
| Record: | 2-9 | 59-48 | |
| Points Scored: | 18.64 | 31.87 | 13.23 |
| Points Allowed: | 31.00 | 27.94 | 3.06 |
| Margin: | -12.36 | 3.93 | 16.29 |
| Total Points: | 49.64 | 59.81 | -10.17 |