| 9/4/2021 | Lafayette | 14 | at | Air Force | 35 | @ MW (1A) | ||
| Colgate | 0 | at | Boston College | 51 | @ ACC (1A) | |||
| Holy Cross | 38 | at | Connecticut | 28 | @ Ind (1A) | |||
| Marist | vs | Georgetown | Canceled COVID | vs Pio | ||||
| Villanova | 47 | at | Lehigh | 3 | CAAF | |||
| Fordham | 7 | at | Nebraska | 52 | @ B10 (1A) | |||
| Bucknell | 0 | at | Sacred Heart | 21 | @ NE | |||
| 9/11/2021 | Stony Brook | 24 | at | Colgate | 3 | CAAF | ||
| Georgetown | 20 | at | Delaware State | 14 | OT | @ MEAC | ||
| Monmouth NJ | 26 | at | Fordham | 23 | BigS | |||
| Merrimack | 35 | at | Holy Cross | 21 | NE | |||
| Lehigh | 3 | at | Richmond | 31 | @ CAAF | |||
| Bucknell | 3 | at | Villanova | 55 | @ CAAF | |||
| Lafayette | 3 | at | William & Mary | 24 | @ CAAF | |||
| 9/18/2021 | Pennsylvania | 30 | at | Bucknell | 6 | Ivy | ||
| William & Mary | 27 | at | Colgate | 7 | CAAF | |||
| Fordham | 14 | at | Florida Atlantic | 45 | @ CUSA (1A) | |||
| Harvard | 44 | at | Georgetown | 9 | Ivy | |||
| New Hampshire | 19 | at | Lafayette | 13 | CAAF | |||
| Princeton | 32 | at | Lehigh | 0 | Ivy | |||
| Holy Cross | 20 | at | Yale | 17 | @ Ivy | |||
| 9/25/2021 | Lehigh | 3 | at | Colgate | 30 | |||
| Georgetown | 24 | at | Columbia | 35 | @ Ivy | |||
| Pennsylvania | 14 | at | Lafayette | 24 | Ivy | |||
| Holy Cross | 45 | at | Monmouth NJ | 15 | @ BigS | |||
| Fordham | 31 | at | Stony Brook | 14 | @ CAAF | |||
| 10/2/2021 | Cornell | 10 | at | Bucknell | 21 | Ivy | ||
| Colgate | 28 | at | Georgetown | 21 | ||||
| Harvard | 38 | at | Holy Cross | 13 | Ivy | |||
| Fordham | 42 | at | Lafayette | 41 | ||||
| Yale | 34 | at | Lehigh | 0 | Ivy | |||
| 10/9/2021 | Colgate | 10 | at | Brown | 31 | @ Ivy | ||
| Wagner | 7 | at | Fordham | 56 | NE | |||
| Bucknell | 0 | at | Lafayette | 27 | ||||
| Lehigh | 0 | at | Pennsylvania | 20 | @ Ivy | |||
| 10/15/2021 | Colgate | 20 | at | Cornell | 34 | @ Ivy | ||
| 10/16/2021 | Bucknell | 21 | at | Fordham | 66 | |||
| Lafayette | 3 | at | Harvard | 30 | @ Ivy | |||
| Georgetown | 14 | at | Holy Cross | 48 | ||||
| 10/23/2021 | Georgetown | 29 | at | Bucknell | 21 | |||
| Lehigh | 28 | at | Fordham | 35 | ||||
| Colgate | 10 | at | Holy Cross | 42 | ||||
| 10/30/2021 | Bucknell | 10 | at | Colgate | 33 | |||
| Lafayette | 24 | at | Georgetown | 23 | ||||
| Holy Cross | 31 | at | Lehigh | 12 | ||||
| 11/6/2021 | Lehigh | 38 | at | Bucknell | 6 | |||
| Fordham | 41 | at | Georgetown | 20 | ||||
| Lafayette | 10 | at | Holy Cross | 35 | ||||
| 11/13/2021 | Bucknell | 10 | at | Army | 63 | @ Ind (1A) | ||
| Holy Cross | 52 | at | Fordham | 24 | ||||
| Colgate | 20 | at | Lafayette | 13 | ||||
| Georgetown | 9 | at | Lehigh | 23 | ||||
| 11/20/2021 | Holy Cross | 45 | at | Bucknell | 6 | |||
| Fordham | 31 | at | Colgate | 45 | ||||
| Lafayette | 10 | at | Lehigh | 17 | ||||
| Georgetown | 21 | at | Morgan State | 28 | @ MEAC | |||
| 11/27/2021 | Sacred Heart | 10 | at | Holy Cross | 13 | NE | ||
| 12/3/2021 | Holy Cross | 16 | at | Villanova | 21 | @ CAAF |