| 9/4/2021 | William & Mary | 0 | at | Virginia (6-6) | 43 | at ACC | ||
| 9/11/2021 | Lafayette (3-8) | 3 | at | William & Mary | 24 | Pat | ||
| 9/18/2021 | William & Mary | 27 | at | Colgate (5-6) | 7 | at Pat | ||
| 9/25/2021 | William & Mary | 34 | at | Elon (6-5,5-3) | 31 | |||
| 10/9/2021 | Albany NY (2-9,1-7) | 24 | at | William & Mary | 31 | |||
| 10/16/2021 | William & Mary | 16 | at | Maine (6-5,4-4) | 27 | |||
| 10/23/2021 | Towson (4-7,3-5) | 14 | at | William & Mary | 40 | |||
| 10/30/2021 | William & Mary | 31 | at | Villanova (10-3,7-1) | 18 | |||
| 11/6/2021 | William & Mary | 3 | at | Delaware (5-6,3-5) | 24 | |||
| 11/13/2021 | James Madison (12-2,7-1) | 32 | at | William & Mary | 22 | |||
| 11/20/2021 | Richmond (6-5,4-4) | 20 | at | William & Mary | 17 |
| vs William & Mary | vs Other Opponents | William & Mary compared to OOs | |
| Record: | 5-6 | 60-56 | |
| Points Scored: | 22.09 | 25.27 | 3.18 |
| Points Allowed: | 22.27 | 23.97 | -1.70 |
| Margin: | -0.18 | 1.30 | 1.48 |
| Total Points: | 44.36 | 49.24 | -4.88 |