| 9/4/2021 | Bucknell (1-10) | 0 | at | Sacred Heart | 21 | Pat | ||
| 9/11/2021 | Sacred Heart | 6 | at | Bryant (7-4,5-2) | 17 | |||
| 9/18/2021 | Morgan State (2-9) | 7 | at | Sacred Heart | 21 | MEAC | ||
| 9/25/2021 | Sacred Heart | 3 | at | Dartmouth (9-1) | 41 | at Ivy | ||
| 10/2/2021 | Sacred Heart | 17 | at | Howard (3-8) | 22 | at MEAC | ||
| 10/9/2021 | Merrimack (5-6,2-5) | 10 | at | Sacred Heart | 20 | |||
| 10/16/2021 | Central Conn (4-7,4-3) | 17 | at | Sacred Heart | 27 | |||
| 10/23/2021 | Duquesne (7-3,5-2) | 13 | at | Sacred Heart | 31 | |||
| 11/6/2021 | Sacred Heart | 14 | at | St Francis PA (5-6,4-3) | 13 | |||
| 11/13/2021 | Wagner (0-11,0-7) | 0 | at | Sacred Heart | 27 | |||
| 11/20/2021 | Sacred Heart | 38 | at | LIU (2-8,2-5) | 14 | |||
| 11/27/2021 | Sacred Heart | 10 | at | Holy Cross (10-3) | 13 | at Pat |
| vs Sacred Heart | vs Other Opponents | Sacred Heart compared to OOs | |
| Record: | 4-8 | 51-68 | |
| Points Scored: | 13.92 | 23.29 | 9.37 |
| Points Allowed: | 19.58 | 28.59 | -9.01 |
| Margin: | -5.66 | -5.30 | 0.36 |
| Total Points: | 33.50 | 51.88 | -18.38 |