| 9/4/2021 | Bowie State (12-2) | 24 | at | Delaware State | 32 | CIAA (D2) | ||
| 9/11/2021 | Georgetown (2-8) | 20 | at | Delaware State | 14 | OT | Pat | |
| 9/18/2021 | Delaware State | 6 | at | East Tennessee St (11-2) | 38 | at SoCon | ||
| 9/25/2021 | Merrimack (5-6) | 47 | at | Delaware State | 10 | NE | ||
| 10/2/2021 | Delaware State | 33 | at | Wagner (0-11) | 27 | OT | at NE | |
| 10/9/2021 | Virginia U-Lynchburg (2-9) | 6 | at | Delaware State | 56 | None (Unk?) | ||
| 10/23/2021 | South Carolina State (7-5,5-0) | 13 | at | Delaware State | 7 | |||
| 10/30/2021 | Howard (3-8,1-4) | 23 | at | Delaware State | 30 | |||
| 11/4/2021 | Delaware State | 14 | at | Morgan State (2-9,1-4) | 20 | |||
| 11/13/2021 | Norfolk State (6-5,2-3) | 26 | at | Delaware State | 28 | |||
| 11/20/2021 | Delaware State | 28 | at | North Carolina Central (6-5,4-1) | 34 | OT |
| vs Delaware State | vs Other Opponents | Delaware State compared to OOs | |
| Record: | 6-5 | 50-65 | |
| Points Scored: | 25.27 | 24.05 | -1.22 |
| Points Allowed: | 23.45 | 29.61 | -6.16 |
| Margin: | 1.82 | -5.56 | -7.38 |
| Total Points: | 48.72 | 53.66 | -4.94 |