| 9/18/2021 | Marist (5-5) | 14 | at | Columbia | 37 | Pio | ||
| 9/25/2021 | Georgetown (2-8) | 24 | at | Columbia | 35 | Pat | ||
| 10/2/2021 | Columbia | 7 | at | Princeton (9-1,6-1) | 24 | |||
| 10/9/2021 | Columbia | 22 | at | Central Conn (4-7) | 20 | at NE | ||
| 10/16/2021 | Pennsylvania (3-7,1-6) | 14 | at | Columbia | 23 | |||
| 10/22/2021 | Columbia | 19 | at | Dartmouth (9-1,6-1) | 0 | |||
| 10/30/2021 | Columbia | 30 | at | Yale (5-5,4-3) | 37 | |||
| 11/6/2021 | Harvard (8-2,5-2) | 49 | at | Columbia | 21 | |||
| 11/13/2021 | Brown (2-8,1-6) | 17 | at | Columbia | 23 | |||
| 11/20/2021 | Columbia | 34 | at | Cornell (2-8,1-6) | 26 |
| vs Columbia | vs Other Opponents | Columbia compared to OOs | |
| Record: | 3-7 | 46-45 | |
| Points Scored: | 22.50 | 26.10 | 3.60 |
| Points Allowed: | 25.10 | 24.92 | 0.18 |
| Margin: | -2.60 | 1.18 | 3.78 |
| Total Points: | 47.60 | 51.02 | -3.42 |